Facile preparation of 3-substituted 2-quinazolinones via electrogenerated base
نویسندگان
چکیده
منابع مشابه
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
A series of 4(3H)-quinazolinones structurally related to 2-methyl-3-o-tolyl-4(3H)-quinazolinone (methaqualone, 3) were synthesized and evaluated for anticonvulsant activity. Preliminary screening of these compounds revealed that 2-[2-oxo-2-(4-pyridyl)ethyl]-3-aryl-4(3H)-quinazolinones 6l and 8i, 8k, and 8p-r having a single ortho substituent on the 3-aryl group had the most promising anticonvul...
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The first highly accelerated Niementowski reaction of anhranilic acid with some amides or ketones under microwave irradiation leading to quinazolinones and quinoline derivatives is described. These reactions represent some examples of efficient microwave irradiation promoted organic condensation in which the reactions can be carried out in open vessels and provides products of high purity w...
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A one-pot Yb(III)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e. quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-α.
متن کاملFacile preparation of allenic hydroxyketones via rearrangement of propargylic alcohols.
[formula: see text] Treatment of tertiary propargylic alcohols 13 with 3-diazo-2-butanone 6 and catalytic dirhodium tetraacetate in benzene gave good yields of the diastereomeric allenic hydroxyketones 14, with, in some cases, good diastereocontrol. These products are presumably formed via the [2,3]-sigmatropic rearrangement of an alpha-propargyloxy enol derivative. This reaction has been exten...
متن کاملmicrowave irradiation promoted the niementowski reaction preparation of substituted quinazolinones and quinolines
the first highly accelerated niementowski reaction of anhranilic acid with some amides or ketones under microwave irradiation leading to quinazolinones and quinoline derivatives is described. these reactions represent some examples of efficient microwave irradiation promoted organic condensation in which the reactions can be carried out in open vessels and provides products of high purity with ...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2018
ISSN: 0040-4020
DOI: 10.1016/j.tet.2018.03.010